Lyrica and Neuropathy: Everything You Need to Know

  • September 4, 2018
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Lyrica and Neuropathy: Everything You Need to Know

A Brief Introduction to Lyrica

Lyrica is widely known as one of the go-to drugs prescribed by doctors for numerous diseases. It boasts an incredible success — and also failure – rate that has been in continuation since it was first released to the public in 2005. After 15 years of studies, clinical trials, and research, inventor Richard Silverman had become a success both in the field of medicine and commercially — totaling in $1.2 billion in sales in 2006. This number has increased over time as Lyrica is now prescribed for more and more diseases and disorders. If you’d like to hear what the FDA have to say about Lyrica, read more here.


5 Fast Facts About Lyrica

Do you want to know more? Read these facts below to gain a better understanding of the drug or skip this section and read “Why Lyrica is Prescribed For Neuropathy“.


I. Lyrica (Pregabalin) has an incredibly high bioavailability

Pregabalin’s bioavailability is quite high. This means that the majority of the drug pregabalin is more likely to enter the circulatory system as opposed to the other ingredients. In turn, the effects of pregabalin are more likely to be felt and noticed — be it good or bad. This is often why you see so many people pro-Lyrica and opposed to Lyrica. It can have profound health benefits if found to be effective and it can also feel quite terrible if it isn’t for you. There isn’t much middle ground because the bioavailability is so high (≥90%).

Want to read more about pregabalin’s bioavailability? Read a study here.


II. Over 9 million people have been prescribed Lyrica and it scored a C by consumers

Out of 1,015 reviews on, Lyrica scored an overall 6.9 out of 10. Click here to see these results for yourself!


III. Lyrica is often prescribed for the following conditions:

  • Fibromyalgia
  • Trigeminal neuralgia
  • Epilepsy
  • Neuropathy
  • Spinal stenosis
  • Restless leg syndrome


IV. There are no generic versions of Lyrica

There are no known FDA-approved generic versions of Lyrica. However, fraudulent companies do sell a type of Lyrica that is potentially unsafe for consumption. We recommend talking to your doctor about these companies prior to ordering anything.


IV. Lyrica comes in 3 different dosage strengths:

  1. 82.5 mg
  2. 165 mg
  3. 330 mg

These different dosages vary from person to person, however, more severe cases warrant Lyrica CR — Lyrica’s premier extended-release tablets. Click here to read more about Lyrica CR.

Want to read more about Lyrica? Click here to be rerouted to Lyrica’s website.

BONUS: Pregabalin is the first drug to receive approved labeling from the FDA for the treatment of diabetic neuropathy.

  • Not just neuropathy, but seizures and anxiety disorders as well! Read more here.


Why Lyrica is Prescribed For Neuropathy

Neuropathy is caused by damage to the nerves. It has many different causes but it all boils down to the same thing: damaged to the myelin sheath surrounding the nerve or direct damage to the nerve. 

Lyrica’s original intention was to stop seizures, or at least prevent them for a duration. GABA is a neurotransmitter that alters brain function. If GABA levels fall too low in some people, seizures have occurred. Richard Silverman and his team created Lyrica to try to prevent GABA levels from falling or depleting. Over time, Lyrica has also given relief to some suffering from nerve damage, or neuropathy.

Study 1: Pregabalin and Neuropathic Pain

Study 2: Pregabalin for the Treatment of Neuropathic Pain

Study 3: Study of Lyrica in Patients With Painful Neuropathy


Pulled directly from their website:

LYRICA (pregabalin) is believed to work within your body to calm the damaged or overactive nerves that can cause diabetic nerve pain. Although the exact mechanism of action is unknown, results from animal studies suggest that pregabalin works by calming damaged or overactive nerves that cause pain or seizures. The implication of these studies in humans is not known.

Summary: no one has a definitive answer to why Lyrica works on some suffers, but it has been known to help. 

Some researchers have come to the conclusion that GABA levels are to blame for neuropathic pain and alleviation. Others disagree and believe it has anti-hyperalgesic and anti-allodynic actions.

Read more on this study here: Pregabalin in Neuropathic Pain: Evidence and Possible Mechanisms

However, I read through every study. In this study from NCBI, it notes that pregabalin is responsible for alleviating symptoms of various types of neuropathic pain. It also says that it does so with “remarkable safety”, which I find surprising. Read below to find out why.


Side Effects of Lyrica

The side effects of Lyrica are just as famous as the medication itself.

  1. Easy bruising
  2. Skin sores (diabetes sufferers primarily)
  3. Vision problems
  4. Unusual bleeding
  5. Rapid weight gain
  6. Swelling in extremities
  7. Muscle pain
  8. Tenderness
  9. Weakness
  10. Fever
  11. Urine discoloration
  12. Worsening of anxiety
  13. Worsening of depression
  14. Worsening of panic attacks
  15. Difficulty concentrating

When someone is suffering from neuropathic pain, the side effects often take a back seat — in terms of priority. This can be detrimental to progression in the right direction or a very good move to ease your pain. Just be sure to be as informed as possible when decided whether or not to try Lyrica.


Conclusion and What To Do Next

Lyrica has helped over 9 million people worldwide. However, that doesn’t mean it is right for you. It also doesn’t mean it is wrong for you! Do yourself a favor and follow these tips:

  • Understand the ins and outs of neuropathy and how it affects you personally. Read more here:
  • Understand how your diet can affect your symptoms. Read more here: 6 Most Effective Diet Changes for Easing Nerve Pain
  • Consult your doctor prior to making any changes to any aspect of your life!
  • Please go through our blogs and research our work. We try to put out thoroughly engaging and insightful content monthly! Click here to read our blogs.
  • Research Lyrica for yourself! You know your body better than anyone else, save your doctor.
  • Do what you can to prevent your neuropathy from getting worse. There are many, many tips out there but we’ve conveniently compiled them into one easy-to-read blog. Read more: Top 7 Ways to Slow the Advancement of Neuropathy.

As always, thank you for being a follower and we look forward to bringing you engaging, thoughtful, and factual content again soon.

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  • The causes of Neuropathy and the little known tricks to reduce the symptoms. The top natural, but highly effective, ways to reduce the pain, numbness and burning
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