FAQ's


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Methylcobalamin
Benfotiamine (a new, more effective, form of B1)
Stabilized R-Alpha lipoic Acid (the most effective anti-oxidant for nerve damage)

The most common B12 used in supplements is called Cyanocobalamine (Cobalamine). The body must convert Cobalamine to Methylcobalamine in order to get adequate levels of Methylcobalamine into the blood system. As the body gets older, it loses its ability to convert Cobalamine to Methylcobalamine and the body absorb as little as 1% of the amount taken.
Methylcobalamine is the form of vitamin B12 that can be directly utilized by the body and is easily absorbed. It is now available in our proprietary blend.

Benfotiamine is a new type of vitamin B1. It is fat-soluble unlike Thiamine B1 which is water soluble. The result is that Benfotiamine can dramatically increase the levels of B1 in the blood stream, and effectively decrease or eliminate nerve pain.
Studies have shown Benfotiamine to be absorbed 360% better than other, more common, forms of vitamin B1.

Several Clinical Trials have shown that R-Alpha Lipoic Acid can have a very positive effect on sufferers of nerve pain. R-ALA has been shown to be up to 12 times more effective the the cheaper and more common S-Alpha Lipoic Acid. Neuropathy Treatment Group ONLY uses stabilized R-ALA because of its superior efficacy and absorbability compared to the common S-ALA found in most supplements. Stabilized R-ALA is also able to withstand temperatures above 90 degrees fahrenheit (like in the back of a mail truck) without hardening into an unusable product. Doctors have made the following statements about the effects of alpha-lipoic acid on nerve health: (full excerpts can be found on our “clinical studies” page)
“The antioxidant therapy with R-ALA improves and may prevent nerve damage”
“…treatment with alpha-lipoic acid over 3 weeks is safe and effective in reducing symptoms of peripheral neuropathy.”
“Oral treatment with R-Alpha Lipoic Acid for 5 weeks improved symptoms”

There have been numerous clinical trials using these supplements and there have been no reports of any negative side effects, even in much higher doses than we are using in Nerve Renew.

Numerous case studies have proven you can take vitamin B supplements without negative effects to your medications. You should always check with a health care professional before taking any new supplements.

The FDA has set no limits on the maximum intake of vitamins B1 and B12. There have been numerous clinical trials using these supplements and there have been no reports of any negative side effects.
In fact, in several clinical studies, far higher doses of these vitamins were used with no reported interactions or negative side effects.

Because of the high quality of our production process, the vitamins in our product will enter your system much faster than other supplements. Some patients have seen results in a little as a week.
Each person is different and it may take longer for Nerve Renew to reach its full potential in your system. Although we have seen a great success rate with our formula, it does not work for everyone. For the best chance of success, we recommend staying on the formula for at least 4 months.

Each bottle of Nerve Renew is stamped with a “Date of Manufacture” (DOM), we recommend you use the product within 18 months of the DOM.

Our 100% money back guarantee covers your most recent order for 1 year from the time of purchase. If you are not satisfied for any reason, just let us know and we will issue you a full refund (minus S&H). See our Terms and Conditions for full details.

Fill out the free sample form HERE and we will rush your trial bottle. You will also be eligible for a 30% savings on your monthly supply.

If you decide that Nerve Renew isn’t right for you, we want it to be as easy as possible to cancel any future shipments. There are 2 easy ways to cancel:
1. Call our our toll free number 24 hours a day, 7 days a week to reach our cancellation line.
2. Send us a message from our Contact Us page with your name, phone number and address and we will process your request within 24 hours.

We charge your card $6.97 for shipping and handling. With your free trial, we also enroll you in our customer loyalty program where a 30 day supply is sent to you each month for only $49. One time orders can be placed for $69 per bottle and are not eligible for the free trial bottle.
Most orders leave our warehouse within 24 hours. If you select our priority shipping option, your order will receive priority processing from our facility and will get to your sooner.

Yes, and you don’t even need to pay extra. To avoid customs fees and delays, we ship international orders via USPS. Depending on your country, international orders can take an extra 2-4 weeks to arrive. We have successfully shipped to over 100 countries outside the USA.

Vitamin B12 and B1 injections have been used by the medical community for many years in trying to relieve the pain associated with damaged nerves. More and more doctors agree that supplementation shows beneficial results and are getting behind many of these products. A daily regiment of Nerve Renew nutritionally supports the body to rapidly and effectively decrease or eliminate the symptoms of nerve pain.
Don’t take our word for it, check out our clinical studies page to see for yourself.

We proudly manufacture each and every component locally in Boise, ID. We don’t outsource any of our customer service positions overseas and proudly support the local economy.

Clinical Studies


There have been numerous studies over the last several years that have shown the effectiveness of the ingredients found in Nerve Renew.

Methylcobalamine Clinical Studies

Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy

Ide H Fujiya S Asanuma Y Tsuji M Sakai H Agishi Y, Clin Ther (1987) 9(2):183-92

Seven men and four women with symptomatic diabetic neuropathy were treated with methylcobalamine (2,500 micrograms in 10 ml of saline) injected intrathecally. Treatment was begun when patients had good metabolic control, as determined by measurements of plasma glucose and hemoglobin, and was repeated several times with a one-month interval between injections. Three patients were re-treated one year after the last intrathecal injection. Symptoms in the legs, such as paresthesia, burning pains, and heaviness, dramatically improved. The effect appeared within a few hours to one week and lasted from several months to four years. The mean peroneal motor-nerve conduction velocity did not change significantly. The mean (+/- SD) concentration of methylcobalamin in spinal fluid was 114 +/- 32 pg/ml before intrathecal injection (n = 5) and 4,752 +/- 2,504 pg/ml one month after intrathecal methylcobalamin treatment (n = 11). Methylcobalamine caused no side effects with respect to subjective symptoms or characteristics of spinal fluid. These findings suggest that a high concentration of methylcobalamin in spinal fluid is highly effective and safe for treating the symptoms of diabetic neuropathy.

Yaqub BA, Siddique A, Sulimani R.
Division of Neurology, King Khalid University Hospital, Riyadh, Saudi Arabia.

We studied the clinical and neurophysiological effects of methylcobalamin on patients with diabetic neuropathy. In a double-blind study, the active group showed statistical improvement in the somatic and autonomic symptoms with regression of signs of diabetic neuropathy. Motor and sensory nerve conduction studies showed no statistical improvement after 4 months. The drug was easily tolerated by the patients and no side effects were encountered.

Watanabe T Kaji R Oka N Bara W Kimura J, J Neurol Sci (1994 Apr) 122(2):140-3

Despite intensive searches for therapeutic agents, few substances have been convincingly shown to enhance nerve regeneration in patients with peripheral neuropathies. Recent biochemical evidence suggests that an ultra-high dose of methylcobalamin may up-regulate gene transcription and thereby protein synthesis. We examined the effects of ultra-high dose of methylcobalamine on the rate of nerve regeneration in rats with acrylamide neuropathy, using the amplitudes of compound muscle action potentials (CMAPs) after tibial nerve stimulation as an index of the number of regenerating motor fibers. After intoxication with acrylamide, all the rats showed equally decreased CMAP amplitudes. The animals were then divided into 3 groups; rats treated with ultra-high (500 micrograms/kg body weight, intraperitoneally) and low (50 micrograms/kg) doses of B12, and saline-treated control rats. Those treated with ultra-high dose showed significantly faster CMAP recovery than saline-treated control rats, whereas the low-dose group showed no difference from the control. Morphometric analysis revealed a similar difference in fiber density between these groups. Ultra-high doses of methylcobalamine may be of clinical use for patients with peripheral neuropathies.

Methylcobalamine Promotes Regeneration of Motor Nerve
Terminals Degenerating in anterior gracile muscle of
gracile axonal dystrophy (GAD) mutant mouse

Yamazaki K Oda K Endo C Kikuchi T Wakabayashi T, Neurosci Lett
(1994 Mar 28) 170(1):195-7

We examined the effects of methylcobalamin on degeneration of motor nerve terminals in the anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mice. GAD mice received orally methylcobalamine (1 mg/kg body wt/day) from the 40th day after birth for 25 days. In the distal endplate zone of the muscle, although most terminals were degenerated in both the untreated and methylcobalamine treated GAD mice, sprouts were more frequently observed in the latter. In the proximal endplate zone, where few degenerated terminals were seen in both groups of the mice, the perimeter of the terminals was increased and the area of the terminals was decreased significantly in the methylcobalamine-treated GAD mice. These findings indicate that methylcobalamine promotes regeneration of degenerating nerve terminals in GAD mice.

Protective Effects of Methylcobalamine, A Vitamin B12 Analogue, Against Glutamate-induced Neurotoxicity in Retinal Cell Culture

Kikuchi M Kashii S Honda Y Tamura Y Kaneda K Akaike, Invest Ophthalmol Vis Sci (1997 Apr) 38(5):848-54

Purpose: To examine the effects of methylcobalamine on glutamate- induced neurotoxicity in the cultured retinal neurons. Methods: Primary cultures obtained from the fetal rat retina (gestation days 16 to 19) were used for the experiment. The neurotoxicity was assessed quantitatively using the trypan blue exclusion method. Results: Glutamate neurotoxicity was prevented by chronic exposure to methylcobalamine and S-adenosylmethionine (SAMe), which is formed in the metabolic pathway of methylcobalamin. Chronic exposure to methylcobalamine and SAMe also inhibited the neurotoxicity induced by sodium nitroprusside that release nitric oxide. By contrast, acute exposure to methylcobalamine did not protect retinal neurons against glutamate neurotoxicity. Conclusions: Chronic administration of methylcobalamine protects cultured retinal neurons against glutamate neurotoxicity, probably by altering the membrane properties through SAMe-mediated methylation.

Protective effects of a vitamin B12 analogue, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons

Akaike A Tamura Y Sato Y Yokota T, Eur J Pharmacol (1993 Sep 7) 241(1):1-6

The effects of methylcobalamin, a vitamin B12 analogue, on glutamate-induced neurotoxicity were examined using cultured rat cortical neurons. Cell viability was markedly reduced by a brief exposure to glutamate followed by incubation with glutamate-free medium for 1 h. Glutamate cytotoxicity was prevented when the cultures were maintained in methylcobalamin-containing medium. Glutamate cytotoxicity was also prevented by chronic exposure to S-adenosylmethionine, which is formed in the metabolic pathway of methylcobalamin. Chronic exposure to methylcobalamin and S- adenosylmethionine also inhibited the cytotoxicity that releases nitric oxide. In cultures maintained in a standard medium, glutamate cytotoxicity was not affected by adding methylcobalamin to the glutamate-containing medium. In contrast, acute exposure to MK-801, a NMDA receptor antagonist, prevented glutamate cytotoxicity. These results indicate that chronic exposure to methylcobalamin protects cortical neurons against NMDA receptor-mediated glutamate cytotoxicity.

Benfotiamine Clinical Studies

Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy.

Arzneimittelforschung 1999 Mar; 49(3): 220-4. Winkler G, Pal B, Nagybeganyi E, Ory I, Porochnavec M, Kempler P.

The therapeutic effectiveness of a benfotiamine (CAS 22457-89-2)-vitamin B combination (Milgamma-N), administered in high (4 x 2 capsules/day, = 320 mg benfotiamine/day) and medium doses (3 x 1 capsules/day), was compared to a monotherapy with benfotiamine (Benfogamma) (3 x 1 tablets/day, = 150 mg benfotiamine/day) in diabetic patients suffering from painful peripheral diabetic neuropathy (DNP). In a 6-week open clinical trial, 36 patients (aged 40 to 70 yrs) having acceptable metabolic control (HbA1c < 8.0%) were randomly assigned to three groups, each of them comprising 12 participants. Neuropathy was assessed by five parameters: the pain sensation (evaluated by a modified analogue visual scale), the vibration sensation (measured with a tuning fork using the Riedel-Seyfert method) and the current perception threshold (CPT) on the peroneal nerve at 3 frequencies: 5, 250 and 2000 Hz). Parameters were registered at the beginning of the study and at the end of the 3rd and 6th week of therapy. An overall beneficial therapeutic effect on the neuropathy status was observed in all three groups during the study, and a significant improvement in most of the parameters studied appeared already at the 3rd week of therapy (p < 0.01). The greatest change occurred in the group of patients receiving the high dose of benfotiamine (p < 0.01 and 0.05, resp., compared to the other groups). Metabolic control did not change over the study. It is concluded that benfotiamine is most effective in large doses, although even in smaller daily dosages, either in combination or in monotherapy, it is effective.

Pharmacokinetics of thiamine derivatives especially of benfotiamine.

Int J Clin Pharmacol Ther 1996 Feb; 34(2): 47-50. Loew D.

Pharmacokinetic data of orally administered lipid-soluble thiamine analogues like benfotiamine are reviewed and assessed. It is quite clear that benfotiamine is absorbed much better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine, the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates. The physiological activity (alphaETK) increased only after benfotiamine was given. Due to its excellent pharmacokinetic profile benfotiamine should be preferred in treatment of relevant indications.

Exp Clin Endocrinol Diabetes 1996; 104(4): 311-6.
Stracke H, Lindemann A, Federlin K.

In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. The results showed a significant improvement (p = 0.006) of nerve conduction velocity in the peroneal nerve and a statistical trend toward improvement of the vibration perception threshold. Long-term observation of 9 patients with verum over a period of 9 months support the results. Therapy-specific adverse effects were not seen. The results of this double-blind investigation, of the long-term observation and of the reports in the literature support the contention that the neurotropic benfotiamine-vitamin B combination represents a starting point in the treatment of diabetic polyneuropathy.

Benfotiamine inhibits intracellular formation of advanced Glycation end products in vivo

Diabetes. 2000 May; 49(Suppl1): A143(P583). Lin J, Alt A, Liersch J, Bretzel RG, Brownlee MA, Hammes HP.

We have demonstrated previously that intracellular formation of the advanced glycation end product (AGE) N-[Epsilon]-(carboxymethyl)lysine (CML) inversely correlates with diabetic vascular complications independently from glycemia (Diabetologia 42, 603, 1999). Here, we studied the effect of benfotiamine, a lipid-soluble thiamine derivative with known AGE-inhibiting properties in-vitro on the intracellular formation of (CML) and methylglyoxal-derived AGE in red blood cells. Blood was collected from 6 Type 1 diabetic patients (2m, 4f, age 31.8 ± 5.5 years; diabetes duration 15.3 ± 7.0 years) before and after treatment with 600 mg/day benfotiamine for 28 days. In addition to HbA1c (HPLC), CML and methylglyoxal were measured using specific antibodies and a quantitative blot technique. While treatment with benfotiamine did not affect HbA1c levels (at entry: 7.18 ± 0.86%; at conclusion 6.88 ± 0.88%; p not significant), levels of CML decreased by 40% (737 ± 51 arbitrary units/mg protein (AU) vs 470 ± 86 AU; p<0.01). The levels of intracellular methylglyoxal were reduced by almost 70% (1628 ± AU vs 500 ± 343 AU; p<0.01). The data indicate that thiamine derivatives are effective inhibitors of both intracellular glycoxidation and AGE formation.

Summary:Advanced glycation end product (AGE) has been linked to many age related illnesses such as cataract development, Alzheimer’s Disease, cardiovascular disease, strokes and reduced muscle function. In this study, benfotiamine was shown to inhibit (AGE) development which in turn leads to decresed risk for these diseases.

Diabetics are at risk for AGE formation beyond normal levels.

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Nat Med 2003 Mar; 9(3): 294-9. Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M.

Three of the major biochemical pathways implicated in the pathogenesis of hyperglycemia induced vascular damage (the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway) are activated by increased availability of the glycolytic metabolites glyceraldehyde-3-phosphate and fructose-6-phosphate. We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars. In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and NF-kappaB activation by activating transketolase, and also prevented experimental diabetic retinopathy. The ability of benfotiamine to inhibit three major pathways simultaneously might be clinically useful in preventing the development and progression of diabetic complications.

Summary:Advanced glycation end product (AGE) has been linked to many age related illnesses such as cataract development, Alzheimer’s Disease, cardiovascular disease, strokes and reduced muscle function. In this study, benfotiamine was shown to inhibit (AGE) development which in turn leads to decresed risk for these diseases.

Diabetics are at risk for AGE formation beyond normal levels.

Prevention of cardiac autonomic neuropathy in dogs with Benfotiamine.

Koltai MZ. In Gries FA, Federlin K. Benfotiamin in the Therapy of Polyneuropathy.
New York: Georg Thieme Verlag, 1998; 45-9.

Experimentally-induced diabetes of the dog leads to disturbances in the autonomous neurological function of the heart after approximately 3 months of continuously- observed diabetes. As signs of autonomic cardiac neuropathy, the heart rate variability and Valsalva ratio clearly fell in the untreated diabetic animals. Oral benfotiamine, administered from the sixth day after diabetes-induction, prevented or at least delayed these changes. According to the results, treatment with fat-soluble benfotiamine can play an important role in the therapy and prevention of cardiac autonomic neuropathy, apart from any effect on diabetic metabolic disturbances.

Alpha-Lipoic Acid Clinical Studies

Ziegler D, Ametov A, Barinov A, et al. The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70]

http://www.ncbi.nlm.nih.gov/pubmed/17065669

OBJECTIVE: The aim of this trial was to evaluate the effects of alpha-lipoic acid (ALA) on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy (DSP).

RESEARCH DESIGN AND METHODS: In this multicenter, randomized, double-blind, placebo-controlled trial, 181 diabetic patients in Russia and Israel received once-daily oral doses of 600 mg (n = 45) (ALA600), 1,200 mg (n = 47) (ALA1200), and 1,800 mg (ALA1800) of ALA (n = 46) or placebo (n = 43) for 5 weeks after a 1-week placebo run-in period. The primary outcome measure was the change from baseline of the Total Symptom Score (TSS), including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet. Secondary end points included individual symptoms of TSS, Neuropathy Symptoms and Change (NSC) score, Neuropathy Impairment Score (NIS), and patients’ global assessment of efficacy.

RESULTS: Mean TSS did not differ significantly at baseline among the treatment groups and on average decreased by 4.9 points (51%) in ALA600, 4.5 (48%) in ALA1200, and 4.7 (52%) in ALA1800 compared with 2.9 points (32%) in the placebo group (all P < 0.05 vs. placebo). The corresponding response rates (>/=50% reduction in TSS) were 62, 50, 56, and 26%, respectively. Significant improvements favoring all three ALA groups were also noted for stabbing and burning pain, the NSC score, and the patients’ global assessment of efficacy. The NIS was numerically reduced. Safety analysis showed a dose-dependent increase in nausea, vomiting, and vertigo.

CONCLUSIONS: Oral treatment with Alpha-Lipoic Acid for 5 weeks improved neuropathic symptoms and deficits in patients with Distal Symmetric Polyneuropathy. An oral dose of 600 mg once daily appears to provide the optimum risk-to-benefit ratio.

Ziegler D, Gries FA. Diabetes. 1997;46 (suppl 2):S62–66.

http://www.ncbi.nlm.nih.gov/pubmed/9285502

Antioxidant treatment has been shown to prevent nerve dysfunction in experimental diabetes, providing a rationale for a potential therapeutic value in diabetic patients. The effects of the antioxidant alpha-lipoic acid (thioctic acid) were studied in two multicenter, randomized, double-blind placebo-controlled trials. In the Alpha-Lipoic Acid in Diabetic Neuropathy Study, 328 patients with NIDDM and symptomatic peripheral neuropathy were randomly assigned to treatment with intravenous infusion of alpha-lipoic acid using three doses (ALA 1,200 mg; 600 mg; 100 mg) or placebo (PLAC) over 3 weeks. The total symptom score (TSS) (pain, burning, paresthesia, and numbness) in the feet decreased significantly from baseline to day 19 in ALA 1,200 and ALA 600 vs. PLAC. Each of the four individual symptom scores was significantly lower in ALA 600 than in PLAC after 19 days (all P < 0.05). The total scale of the Hamburg Pain Adjective List (HPAL) was significantly reduced in ALA 1,200 and ALA 600 compared with PLAC after 19 days (both P < 0.05). In the Deutsche Kardiale Autonome Neuropathie Studie, patients with NIDDM and cardiac autonomic neuropathy diagnosed by reduced heart rate variability were randomly assigned to treatment with a daily oral dose of 800 mg alpha-lipoic acid (ALA) (n = 39) or placebo (n = 34) for 4 months. Two out of four parameters of heart rate variability at rest were significantly improved in ALA compared with placebo. A trend toward a favorable effect of ALA was noted for the remaining two indexes. In both studies, no significant adverse events were observed. In conclusion, intravenous treatment with alpha-lipoic acid (600 mg/day) over 3 weeks is safe and effective in reducing symptoms of diabetic peripheral neuropathy, and oral treatment with 800 mg/day for 4 months may improve cardiac autonomic dysfunction in NIDDM.

Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.

http://care.diabetesjournals.org/content/18/8/1160.abstract

OBJECTIVE–To determine whether lipoic acid (LA) will reduce oxidative stress in diabetic peripheral nerves and improve neuropathy. RESEARCH DESIGN AND METHODS–We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats. LA, in doses of 20, 50, and 100 mg/kg, was administered intraperitoneally five times per week after onset of diabetes. RESULTS–NBF in SDN was reduced by 50%; LA did not affect the NBF of normal nerves but improved that of SDN in a dose-dependent manner. After 1 month of treatment, LA-supplemented rats (100 mg/kg) exhibited normal NBF. The most sensitive and reliable indicator of oxidative stress was reduction in reduced glutathione, which was significantly reduced in streptozotocin-induced diabetic and alpha-tocopherol-deficient nerves; it was improved in a dose-dependent manner in LA-supplemented rats. The conduction velocity of the digital nerve was reduced in SDN and was significantly improved by LA. CONCLUSIONS–These studies suggest that LA improves SDN, in significant part by reducing the effects of oxidative stress. The drug may have potential in the treatment of human diabetic neuropathy.

Packer L, Kraemer K, Rimbach G. Nutrition. 2001;17(10):888-895.

http://www.ncbi.nlm.nih.gov/pubmed/11684397

Alpha-lipoic acid (LA) and its reduced form, dihydrolipoic acid, are powerful antioxidants. LA scavenges hydroxyl radicals, hypochlorous acid, peroxynitrite, and singlet oxygen. Dihydrolipoic acid also scavenges superoxide and peroxyl radicals and can regenerate thioredoxin, vitamin C, and glutathione, which in turn can recycle vitamin E. There are several possible sources of oxidative stress in diabetes including glycation reactions, decompartmentalization of transition metals, and a shift in the reduced-oxygen status of the diabetic cells. Diabetics have increased levels of lipid hydroperoxides, DNA adducts, and protein carbonyls. Available data strongly suggest that LA, because of its antioxidant properties, is particularly suited to the prevention and/or treatment of diabetic complications that arise from an overproduction of reactive oxygen and nitrogen species. In addition to its antioxidant properties, LA increases glucose uptake through recruitment of the glucose transporter-4 to plasma membranes, a mechanism that is shared with insulin-stimulated glucose uptake. Further, recent trials have demonstrated that LA improves glucose disposal in patients with type II diabetes. In experimental and clinical studies, LA markedly reduced the symptoms of diabetic pathologies, including cataract formation, vascular damage, and polyneuropathy. To develop a better understanding of the preventative and therapeutic potentials of LA, much of the current interest is focused on elucidating its molecular mechanisms in redox dependent gene expression.

Ziegler D, Reljanovic M, Mehnert H, Gries FA. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.

http://www.ncbi.nlm.nih.gov/pubmed/10595592

Diabetic neuropathy represents a major health problem, as it is responsible for substantial morbidity, increased mortality, and impaired quality of life. Near-normoglycaemia is now generally accepted as the primary approach to prevention of diabetic neuropathy, but is not achievable in a considerable number of patients. In the past two decades several medical treatments that exert their effects despite hyperglycaemia have been derived from the experimental pathogenetic concepts of diabetic neuropathy. Such compounds have been designed to improve or slow the progression of the neuropathic process and are being evaluated in clinical trials, but with the exception of alpha-lipoic acid (thioctic acid) which is available in Germany, none of these drugs is currently available in clinical practice. Here we review the current evidence from the clinical trials that assessed the therapeutic efficacy and safety of thioctic acid in diabetic polyneuropathy. Thus far, 15 clinical trials have been completed using different study designs, durations of treatment, doses, sample sizes, and patient populations. Within this variety of clinical trials, those with beneficial effects of thioctic acid on either neuropathic symptoms and deficits due to polyneuropathy or reduced heart rate variability resulting from cardiac autonomic neuropathy used doses of at least 600 mg per day. The following conclusions can be drawn from the recent controlled clinical trials. 1.) Short-term treatment for 3 weeks using 600 mg of thioctic acid i.v. per day appears to reduce the chief symptoms of diabetic polyneuropathy. A 3-week pilot study of 1800 mg per day given orally indicates that the therapeutic effect may be independent of the route of administration, but this needs to be confirmed in a larger sample size. 2.) The effect on symptoms is accompanied by an improvement of neuropathic deficits. 3.) Oral treatment for 4-7 months tends to reduce neuropathic deficits and improves cardiac autonomic neuropathy. 4.) Preliminary data over 2 years indicate possible long-term improvement in motor and sensory nerve conduction in the lower limbs. 5.) Clinical and postmarketing surveillance studies have revealed a highly favourable safety profile of the drug. Based on these findings, a pivotal long-term multicenter trial of oral treatment with thioctic acid (NATHAN I Study) is being conducted in North America and Europe aimed at slowing the progression of diabetic polyneuropathy using a clinically meaningful and reliable primary outcome measure that combines clinical and neurophysiological assessment.

Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.

http://www.ncbi.nlm.nih.gov/pubmed/11134258

Antioxidants, in particular vitamin E (VE), have been reported to protect against diabetic renal injury. alpha-Lipoic acid (LA) has been found to attenuate diabetic peripheral neuropathy, but its effects on nephropathy have not been examined. In the present study, parameters of glomerular injury were examined in streptozotocin diabetic rats after 2 mo on unsupplemented diets and in diabetic rats that received the lowest daily dose of dietary LA (30 mg/kg body wt), VE (100 IU/kg body wt), or vitamin C (VC; 1 g/kg body wt), which detectably increased the renal cortical content of each antioxidant. Blood glucose values did not differ among the diabetic groups. At 2 mo, inulin clearance, urinary albumin excretion, fractional albumin clearance, glomerular volume, and glomerular content of immunoreactive transforming growth factor-beta (TGF-beta) and collagen alpha1 (IV) all were significantly increased in unsupplemented D compared with age-matched nondiabetic controls. With the exception of inulin clearance, LA prevented or significantly attenuated the increase in all of these glomerular parameters in D, as well as the increases in renal tubular cell TGF-beta seen in D. At the dose used, VE reduced inulin clearance in D to control levels but failed to alter any of the other indices of glomerular injury or to suppress renal tubular cell TGF-beta in D. VC suppressed urinary albumin excretion, fractional albumin clearance, and glomerular volume but not glomerular or tubular TGF-beta or glomerular collagen alpha1 (IV) content. LA but not VE or VC significantly increased renal cortical glutathione content in D. These data indicate that LA is effective in the prevention of early diabetic glomerular injury and suggest that this agent may have advantages over high doses of either VE or VC.

Lynch MA. Nutr Neurosci. 2001;4(6):419-438.

http://www.ncbi.nlm.nih.gov/pubmed/11843262

In the past decade or so, a convincing link between oxidative stress and degenerative conditions has been made and with the knowledge that oxidatiye changes may actually trigger deterioration in cell function, a great deal of energy has focussed on identifying agents which may have possible therapeutic value in combating oxidative changes. One agent which has received attention, because of its powerful antioxidative effects, particularly in neuronal tissue, is lipoic acid.

Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.

http://www.ncbi.nlm.nih.gov/pubmed/11752027

Previous studies demonstrated that 2 mo of dietary supplementation with alpha-lipoic acid (LA) prevented early glomerular injury in non-insulin-treated streptozotocin diabetic rats (D). The present study examined the effects of chronic LA supplementation (30 mg/kg body wt per d) on nephropathy in D after 7 mo of diabetes. Compared with control rats, D developed increased urinary excretion of albumin and transforming growth factor beta, renal insufficiency, glomerular mesangial matrix expansion, and glomerulosclerosis in association with depletion of glutathione and accumulation of malondialdehyde in renal cortex. LA prevented or ameliorated all of these changes in D. Because chronic LA supplementation also attenuated hyperglycemia in D after 3 mo, its effects on renal injury were compared with treatment of rats with sufficient insulin to maintain a level of glycemic control for the entire 7-mo period (D-INS) equivalent to that observed with LA during the final 4 mo. Despite superior longitudinal glycemic control in D-INS, urinary excretion of albumin and transforming growth factor beta, glomerular mesangial matrix expansion, the extent of glomerulosclerosis, and renal cortical malondialdehyde content were all significantly greater, whereas cortical glutathione content was lower than corresponding values in D given LA. Thus, the renoprotective effects of LA in D were not attributable to improved glycemic control alone but also likely reflected its antioxidant activity. The combined antioxidant and hypoglycemic actions of LA both may contribute to its utility in preventing renal injury and other complications of diabetes.

Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330

http://www.ncbi.nlm.nih.gov/pubmed/10836205

BACKGROUND: The diabetic state, in both humans and experimental animals, is associated with oxidative stress. Lipid peroxidation of nerve membranes has been suggested as a mechanism by which peripheral nerve ischemia and hypoxia could cause neuropathy. Lipoic acid (LA) is a powerful inhibitor of iron-dependent lipid peroxidation and reactive oxygen species. The treatment of diabetic peripheral and cardiac autonomic neuropathy with LA is based on good clinical and experimental evidence.

MATERIALS AND METHODS: To investigate the magnitude of the oxidative stress, serum ceruloplasmin (Cp) and lipid peroxide (Lp) levels were measured in 10 patients with diabetic neuropathy, before and 70 days after treatment with single dose of 600 mg LA/day. For other 12 healthy age- and sex-matched control subjects the serum Cp and Lp levels were evaluated.

RESULTS: Our results show that hyperglycemia is a factor for an increase in serum ceruloplasmin in patients with diabetic neuropathy compared to healthy subjects (p < 0.0001). High serum ceruloplasmin (Cp) level in patients with diabetes may be related to antioxidant defense. The treatment of diabetic neuropathy with LA does not affect significantly the serum Cp activity. The serum Lp levels after LA administration were significantly lower (p < 0.005) than those before treatment.

CONCLUSIONS: The antioxidant therapy with R-ALA improves and may prevent diabetic neuropathy. This improvement is associated with a reduction in the indexes of lipid peroxidation. Oxidative stress appears to be primarily due to the processes of nerve ischemia and hyperglycemia autooxidation.

Contact Us


Our mission as a company is to not only impress you with how well our products work, but to wow you with our customer service and leave a lasting impression. Please feel free to contact us with any questions you have about our product or service.

Our offices are located in beautiful Boise, Idaho and our support team is second to none.

We’re happy to answer your questions and help you any way we can.  Our pledge to you is that we will read every comment and answer every question in a courteous and timely manner.

…and of course  - We’d also love to hear how Nerve Renew has helped you!

So please contact us with any questions or comments.

You can reach us in the following ways:

Mailing Address:
3855 W. Lorenzo Ste. 100
Eagle, ID 83616

Phone:
888-840-7142 (Mon-Sat 7:00AM thru 7:00PM MST)

E-mail:
support@neuropathytreatmentgroup.com

Questions? Comments? Contact Us.



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We stand behind our 100% Money Back Guarantee


We guarantee that Nerve Renew™ will positively affect your life and allow you to live better with nerve pain or you will get 100% of your money back (minus S&H).

Testimonials

We have received so many wonderful testimonials from satisfied users that we couldn’t fit all of them on our main page.

Remember, results vary. Nerve pain has many causes and not everyone will see results. Our testimonials are from real customers who saw results but your results can vary depending on many different factors.



*Results Vary. Nerve Damage has many causes and not everyone will see results using Nerve Renew. All of our testimonials are from real customers who saw real results but your results can vary greatly depending on many factors.

WE STAND BEHIND OUR FORMULA 100%.


If you don’t experience the same amazing results as our testimonials, we offer a 100% money back guarantee (minus S&H charges) for 1 Year on your most recent order. There’s absolutely no risk to you.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

IMPORTANT UPDATE: PRODUCT NAME CHANGE

Same great product, now called “Nerve Renew”

Dear Valued Customer,

We appreciate your continued use of our products and we work hard to offer the best natural products for nerve pain.

Most of you are aware of the product name change that we announced a few months ago. This name improvement has not changed our formulation. The same clinically tested ingredients, dosages and strict manufacturing standards are still in place and will continue to be provided in each capsule and bottle of our formula.

Why are we making these changes?

We recognize that our products are valued by many that suffer from neuropathy as well as other nerve related issues. The name change from “Neuropathy Support Formula" to the new name " Nerve Renew" is simply an effort to broaden visibility to those suffering from various other types of nerve aliments.

Neuropathy Support Formula is now called Nerve Renew!

If you have any comments or questions. Feel free to call us at 1-888-840-7142 or email us at support@neuropathytreatmentgroup.com. We’d love to hear from you. If you have friends or loved ones suffering with nerve pain, don’t let them go another day without trying Nerve Renew, help us spread the word!

Nerve Health Breakthrough. Find out why we are willing to offer a 1 year money back guarantee.

My name is Wes Jones, and I'm the president of the Nerve Renew. We specialize exclusively in the research of natural ways to support and strengthen nerves. If you care about nerve health, you'll want to hear this story about Michael Brady and how he reclaimed his life.

Michael worked as a structural engineer until he had to retire because of the walking that his job required. He eventually had to give up his active lifestyle.

For Michael it all started many years ago with feeling pins and needles around his big toe and as time passed the feeling advanced to his other toes on both feet.

After a few years of this. Michael decided it was time to see his doctor.

"You'll just have to live with it" was his doctor's diagnosis. All he could do for Michael was to prescribe medication, which he stayed on for years.

Michael turned to the internet and found that there were alternatives. He found that some people were getting relief from vitamin B shots. Others were using hot/cold packs but they were not getting the sustained relief that they were looking for.

The medical community treats the condition with anti-depressants, anti-convulsants, steroid and cortisone injections, lidocaine patches and narcotics. Doctors recognize the need for additional solutions but their busy practices make it difficult to stay on top of the current nutritional research.

Michael found a doctor who recommended Vitamin B and Alpha Lipoic Acid shots.

He spent several months going into his office each week for the treatments, but they were costing him a fortune. And it was tough getting in to see the Doctor every week, even though he was experiencing some relief.

His doctor finally suggested that he find a good vitamin B supplement with high concentrations of Vitamin B-1, B-12 and Alpha Lipoic Acid. He felt that in order for the vitamin B to really have an effect, he needed to take it every day. Michael ended up taking 4 different supplements to get the dosages he recommended but it was costing him over $100 a month.

Then one day while searching on the internet, he found Nerve Renew. There is no other formula on the market like this.

It contains the most powerful and clinically studied forms of B vitamins, Stabilized R Alpha Lipoic Acid, anti-oxidants and herbal extracts. All the ingredients have been included in clinical studies and provide a synergistic effect when taken together. And to Michaels delight, Nerve Renew was less expensive.

He showed the ingredients to his doctor and he recommended that Michael continue using the product. Plus, he started recommending Nerve Renew to his other patients.

The following is the letter we received from Michael.

*Dear Neuropathy Treatment Group,

After 10 years of searching, thanks to you, I finally found a product I can stand behind.

My wife and I are riding our bikes again, which I never thought would happen. I have been able to return to my active lifestyle and I am playing golf every week.

I can't thank you enough for this product. I would recommend Nerve Renew to anyone.
Sincerely,

Michael Brady
m.brady23@hotmail.com

*Results Vary. Nerve Damage has many causes and not everyone will see results using Nerve Renew. All of our testimonials are from real customers who saw real results but your results can vary greatly depending on many factors.

What's so unique about the ingredients in Nerve Renew?

3X greater bioavailability

To begin with, Nerve Renew is loaded with vitamin B. So are our competitors, but that's where the similarity between our formula and others ends.

Many nerve supplements contain the common form of vitamin B1 called thiamine. The problem is that your body has a hard time absorbing thiamine. So when you take vitamin B1, you don't get all of the beneficial nutrients your body needs to support nerves. Much of it passes right out of your body in your urine, without doing you a bit of good.

Instead of thiamine, Nerve Renew uses a form of vitamin B1 called benfotiamine.

This molecule has a unique open-ring structure that enables benfotiamine to pass directly through cell membranes into the cell.

An important study in the International Journal of Clinical Pharmacology Therapy found that the bioavailability of benfotiamine is 3.6 X greater than thiamine hydrochloride.

That means when you take Nerve Renew, you get more vitamin B delivered to your cells where it's needed.

In addition, benfotiamine is less toxic than thiamine hydrochloride. And after decades of use by millions of people, there have been no adverse affects reported related to the use of vitamin B-1.

The daily dose of Nerve Renew contains 600mg with a 27,500% daily value rating established by the FDA.

Plus, Nerve Renew also contains another potent B vitamin, B12 or methylcobalamine.

Methylcobalamine is absorbed and used more efficiently than cyanocobalamine, the more common form of vitamin B12 found in most supplements.

The daily dose of our formula contains 4000mcg B12 with a 66,664% daily value rating.

These special forms of vitamin B are effective, but 100% Stabilized R-Alpha Lipoic Acid (R-ALA) is our most important ingredient.

R-Alpha Lipoic Acid is a potent antioxidant that is both fat and water soluble, which improves the function of cell "transporters" that carry and distribute glucose. Most importantly, R-ALA is the only antioxidant that has the unique ability to regenerate itself and other antioxidants such as B vitamins. Many studies, doctors and researchers have shown Stabilized R-ALA to be up to 12 times as effective as the cheaper S-ALA found in most common Alpha Lipoic Acid supplements *.

Our Proprietary Blend of Natural Ingredients

Our research team also found that the medical literature revealed that there are quite a few herbal extracts that can support nerve health.

Of these, our researchers, scientists and doctor formulated a proprietary blend of vitamins and herbal extracts and added it to Nerve Renew.

Vitamin B2 - Our formula contains 8mg at 480% daily value
Vitamin B6 - 8mg at 400% daily value. Studies show that in small doses, B6 can be very beneficial for nerve health. At larger doses in excess of 100mg per day, it can have an adverse effect on nerves.
Vitamin D - 1000IU at 250% daily value
Feverfew extracts have numerous clinical studies
Oat Straw extract
Passion flower
Skullcap extract

How do we guarantee that Nerve Renew is the best supplement money can buy?

Our manufacturing facility is FDA approved and adheres to Good Manufacturing Practices (GMPs) for supplement manufacturers. Our process guarantees the potency, purity and quality in 10 different ways:

  1. The ingredients we use have been shown to be effective in clinical trials.
  2. All of our ingredients match the levels used in clinical trials.
  3. We only use proven growers and suppliers that we've known for years.
  4. All ingredients are lab-tested using NIR (Near-Infrared) to ensure their potency, purity and quality.
  5. All ingredients are screened for contaminants including pesticides and metals.
  6. All ingredients come from natural sources.
  7. Our manufacturing process conforms with or exceeds standards set by the U.S. Government. Our facility undergoes 2 audits per year by a 3rd party that certify that we meet GMP's.
  8. Each ingredient goes through dissolution and disintegration tests ensuring that it will be absorbed into your stomach and intestines.
  9. Every step of our manufacturing process is double checked and signed off by a quality control scientist.
  10. Every bottle is immediately sealed after manufacturing and is marked with an expiration date to ensure freshness and potency.
Speak with a specialist (888) 840-7142
Mon-Fri 7am – 7pm MST, Sat 9am-5pm MST
Click here to order now!

How Fast Will I See The Results? Read What Our Satisfied Users Have To Say...

*Results Vary. Nerve damage has many causes and not everyone will see results using Nerve Renew. All of our testimonials are from real customers who saw real results but your results can vary greatly depending on many factors.

*"Thank you so much"

Doctors gave me nothing that helped. Thank you so much for your wonderful product."

Marilyn Bell - Las Vegas, NV

*"I am beginning to enjoy my active life again"

I had practically given up on being able to wear shoes and do the hiking and bicycling I had previously enjoyed so much.

Thanks to Nerve Renew, I am beginning to enjoy my active life again. I am especially looking forward to cross country skiing this winter!

Jan Knorr - Cranberry Pennsylvania

*"I love this product"

"Your product is wonderful. I love this product before I used to have to buy about 5 different bottles of vitamins."

DJ Spears - Las Vegas, NV

*Results Vary. Nerve damage has many causes and not everyone will see results using Nerve Renew. All of our testimonials are from real customers who saw real results but your results can vary greatly depending on many factors.

Nerve Renew gives you all the support you need at a fraction of the cost

If you tried to purchase the individual ingredients in Nerve Renew at your health food store, you could easily spend the following amounts for a 30 day supply:

What's more, it's so much easier to get these nutrients in one convenient supplement, rather than having to mix and match them yourself. All the work has already been done for you. It's great to know that in these tough economic times, you can count on us to keep this formula affordable

Our 1 Year 100% Money Back Guarantee

We guarantee that if Nerve Renew™ hasn't helped you... or you are not fully satisfied for any other reason (or for no reason at all)... you will get 100% of your money back on your most recent order. (Minus the cost of S&H)

That's right - that means you can try out Nerve Renew at my risk, and request a refund any time within 1 year of your most recent order!

Look: 30 days from now you can be nothing more than a month older, or you can be taking steps towards improving your well being, you decide. You have nothing to fear, because you're protected by a full 1 year guarantee. You have nothing to lose by giving Nerve Renew a try. If it doesn't produce results, I honestly want you to ask for your money back!

I Want To Try This For Myself. How can I get a 2 week sample?

If you were to try and buy all of the ingredients in Nerve Renew, you would spend over $123 and have to take 9 or more capsules per day and you still wouldn't match our proprietary blend and guaranteed potency.

For a limited time, we will send you a free 2 week supply of Nerve Renew and enroll you in our "Preferred Customer Program." You pay just $6.97 to cover shipping and handling.

That's right. You will receive a free trial bottle and membership into our preferred customer program which qualifies you to receive a full $20 discount on all your future bottles of Nerve Renew.

And so you don't go a day without Nerve Renew capsules, you'll automatically receive a fresh bottle every 30 days and your credit card will be billed the preferred member price of $49, plus S&H - not the $69 non members have to pay.
There are no minimum amounts of bottles to buy, and you can pause or cancel at any time. Your trial bottle will give you a full 2 weeks to make sure the product is right for you. At the end of the 2 weeks, if you're not completely satisfied, you can cancel without obligation.

Of course, you can also order a single bottle at our regular price of $69 or a discounted 3 month supply without signing up for our Preferred Customer Program with automatic shipments.

take action today, right now, by looking at the research and ingredients in Nerve Renew and making the same choice that thousands of our customers have already made.

So order today, right now, while it's still hot on your mind. This offer may not last long.

Or Call 888-840-7142 to order by phone
(Mon-Fri 7am – 7pm MST, Sat 9am-5pm MST)

Our 1 Year 100% Money Back Guarantee

We guarantee that if Nerve Renew™ hasn't helped you... or you are not fully satisfied for any other reason (or for no reason at all)... you will get 100% of your money back on your most recent order. (Minus the cost of S&H)

That's right - that means you can try out Nerve Renew at my risk, and request a refund any time within 1 year of your most recent order!

Look: 30 days from now you can be nothing more than a month older, or you can be taking steps towards improving your well being, you decide. You have nothing to fear, because you're protected by a full 1 year guarantee. You have nothing to lose by giving Nerve Renew a try. If it doesn't produce results, I honestly want you to ask for your money back!

Thousands are Already Trying This Formula

Take the time to research our ingredients and we think you'll come to the conclusion that no other formula offers a more complete package.

The ingredients in Nerve Renew have been researched and scrutinized by a team of scientists and doctors, and now you can try it without risk or obligation.

So what are you waiting for? To order Nerve Renew, Just select your order option above or call toll-free 1-888-840-7142 to speak with one of our specialists. Our specialists’ hours are Mon-Sat 7:00am to 7:00pm MST.

It's important to understand that this is not an overnight solution. Results can take time and we recommend that most people plan to continue on Nerve Renew for 3-4 months to reach optimal nerve health*.

A Few More Reasons To Order Today

World Class
Customer Support

Need help with your order? Questions about our formula? Our highly trained specialists would love to hear from you. Contact us anytime by phone or email.

1 Year Money Back
Guarantee

Our industry leading money back guarantee covers your most recent order for up to 1 year! They said we were crazy for offering a 1 year guarantee but we stand behind our product. Try Nerve Renew risk free.

Amazing Customer
Testimonials

Every testimonial on our site is a testament to the power of our formula. Don't take our word for it, read through the testimonials to learn how our formula has changed the lives of thousands of people.

Backed By
Clinical Studies

Nerve Renew only uses ingredients backed by clinical studies. You can find information about these studies on our "Clinical Studies" page and we encourage you to learn about the results for yourself.

Manufacturing Audited
and Certified

Our manufacturing facility follows all GMP's and undergoes voluntary 3rd party audits twice a year. Every ingredient is tested for potency and purity before it is mixed and bottled.

Highest Grade
Ingredients

All of our ingredients are hand selected and tested to be of the highest quality. We always use the most bio-available forms of vitamins. Our lab uses NIR (Near-infrared) technology to test each ingredient that enters our facility.

Clinical Study Links

B12

B1

R-ALA